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Article

Regulation of the Pancreatic Duodenal Homeobox-1 Protein by DNA-dependent Protein Kinase

16 Sept 2005

Abstract excerpt

The transcription factor PDX-1 plays a crucial role during pancreatic development and in the function of insulin-producing beta cells. Disruption of the pdx-1 gene in these cells induces overt diabetes in mice, and this gene is modified in several type 2 diabetic families. It is thus crucial to determine the molecular mechanisms involved in the regulation of PDX-1 expression and/or activation. We identified new...

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PMID: 16166097
DOI: 10.1074/jbc.m504842200

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