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Article

Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.

Molecular cancer - 19 Mar 2010

Lee Chien-Hsing, Hung Hsing-Wen, Hung Pei-Hsin, Shieh Yi-Shing

Abstract excerpt

BACKGROUND: Many cancerous cells accumulate beta-catenin in the nucleus. We examined the role of epidermal growth factor receptor (EGFR) signaling in the accumulation of beta-catenin in the nuclei of oral cancer cells. RESULTS: We used two strains of cultured oral cancer cells, one with reduced EGFR expression (OECM1 cells) and one with elevated EGFR expression (SAS cells), and measured downstream effects, such...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20302655
DOI: 10.1186/1476-4598-9-64
PMCID: PMC2850885

Genes

EGFR
EGF
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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