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Article

Evidence of a large-scale functional organization of mammalian chromosomes.

PLoS genetics - 1 Sept 2005

Petkov Petko M, Graber Joel H, Churchill Gary A, DiPetrillo Keith, King Benjamin L, Paigen Kenneth

Abstract excerpt

Evidence from inbred strains of mice indicates that a quarter or more of the mammalian genome consists of chromosome regions containing clusters of functionally related genes. The intense selection pressures during inbreeding favor the coinheritance of optimal sets of alleles among these genetically linked, functionally related genes, resulting in extensive domains of linkage disequilibrium (LD) among a set of 60...

Topics

Animals
Chromosome Mapping
Chromosomes
Chromosomes, Human
Databases, Nucleic Acid
Genome
Humans
Inbreeding
Linkage Disequilibrium
Mammals
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16163395
DOI: 10.1371/journal.pgen.0010033
PMCID: PMC1201368

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