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Article

Linkage disequilibrium in wild mice.

PLoS genetics - 1 Aug 2007

Laurie Cathy C, Nickerson Deborah A, Anderson Amy D, Weir Bruce S, Livingston Robert J, Dean Matthew D, Smith Kimberly L, Schadt Eric E, Nachman Michael W

Abstract excerpt

Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have been identified. The main difficulty is the extensive linkage disequilibrium (LD) in intercross progeny and the slow process of fine-scale mapping by traditional...

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Identifiers

PMID: 17722986
DOI: 10.1371/journal.pgen.0030144
PMCID: PMC1950958

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Source receipt: pubmed, retrieved 7 Sept 2026.

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