Article
In silico mapping of complex disease-related traits in mice.
Science (New York, N.Y.) - 8 Jun 2001
Grupe A, Germer S, Usuka J, Aud D, Belknap J K, Klein R F, Ahluwalia M K, Higuchi R, Peltz G
Abstract excerpt
Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months down to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic...
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