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Article

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma.

The EMBO journal - 5 Oct 2005

Achanta Geetha, Sasaki Ryohei, Feng Li, Carew Jennifer S, Lu Weiqin, Pelicano Helene, Keating Michael J, Huang Peng

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations and deletions are frequently observed in cancer, and contribute to altered energy metabolism, increased reactive oxygen species (ROS), and attenuated apoptotic response to anticancer agents. The mechanisms by which cells maintain mitochondrial genomic integrity and the reason why cancer cells exhibit more frequent mtDNA mutations remain unclear. Here, we report that the tumor...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16163384
DOI: 10.1038/sj.emboj.7600819
PMCID: PMC1276176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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