Article
Bioluminescence detection of cells having stabilized p53 in response to a genotoxic event.
Molecular imaging - 1 Jan 2004
Rehemtulla Alnawaz, Taneja Neelam, Ross Brian D
Abstract excerpt
Inactivation of p53 is one of the most frequent molecular events in neoplastic transformation. Approximately 60% of all human tumors have mutations in both p53 alleles. Wild-type p53 activity is regulated in large part by the proteosome-dependent degradation of p53, resulting in a short p53 half-life in unstressed and untransformed cells. Activation of p53 by a variety of stimuli, including DNA damage induced by...
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