Regulation of axon guidance by slit and netrin signaling in the Drosophila ventral nerve cord.

doi:10.1534/genetics.107.075085

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Article

Regulation of axon guidance by slit and netrin signaling in the Drosophila ventral nerve cord.

Genetics - 1 Aug 2007

Bhat Krishna Moorthi, Gaziova Ivana, Krishnan Smitha

Abstract excerpt

Netrin and Slit signaling systems play opposing roles during the positioning of longitudinal tracts along the midline in the ventral nerve cord of Drosophila embryo. It has been hypothesized that a gradient of Slit from the midline interacts with three different Robo receptors to specify the axon tract positioning. However, no such gradient has been detected. Moreover, overexpression of Slit at the midline has no...

Topics

Animals
Axonal Transport
Axons
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
DNA Primers
Drosophila
Drosophila Proteins
Epistasis, Genetic
Female
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Nerve Tissue Proteins

Nervous System

Netrin Receptors

Phenotype

Receptors, Cell Surface

Source

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Identifiers

PMID: 17565966
DOI: 10.1534/genetics.107.075085
PMCID: PMC1950628

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Regulation of axon guidance by slit and netrin signaling in the Drosophila ventral nerve cord.PMID 17565966Read ↗

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Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.Semantic proximity Read ↗

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Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.Semantic proximity Read ↗

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slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.Semantic proximity Read ↗

Axon guidance at the midline: from mutants to mechanisms.Semantic proximity Read ↗

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