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Article

The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons.

Neuron - 8 Jul 2004

Marillat Valérie, Sabatier Christelle, Failli Vieri, Matsunaga Eiji, Sotelo Constantino, Tessier-Lavigne Marc, Chédotal Alain

Abstract excerpt

During development, precerebellar neurons migrate dorsoventrally from the rhombic lip to the floor plate. Some of these neurons cross the midline while others stop. We have identified a role for the slit receptor Rig-1/Robo3 in directing this process. During their tangential migration, neurons of all major hindbrain precerebellar nuclei express high levels of Rig-1 mRNA. Rig-1 expression is rapidly downregulated...

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Identifiers

PMID: 15233918
DOI: 10.1016/j.neuron.2004.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons.PMID 15233918Read ↗

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Genetic Dissection of the Function of Hindbrain Axonal CommissuresSemantic proximity Read ↗

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Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.Semantic proximity Read ↗

Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.Semantic proximity Read ↗

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