Fragment-Based Screening in Tandem with Phenotypic Screening Provides Novel Antiparasitic Hits

Abstract excerpt

Methods to discover biologically active small molecules include target-based and phenotypic screening approaches. One of the main difficulties in drug discovery is elucidating and exploiting the relationship between drug activity at the protein target and disease modification, a phenotypic endpoint. Fragment-based drug discovery is a target-based approach that typically involves the screening of a relatively...

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