Article
A case of restless leg syndrome in a family with LRRK2 gene mutation.
The International journal of neuroscience - 1 Apr 2013
De Rosa Anna, Guacci Anna, Peluso Silvio, Del Gaudio Luigi, Massarelli Marco, Barbato Stefano, Criscuolo Chiara, De Michele Giuseppe
Abstract excerpt
LRRK2 gene mutations (PARK8) are a common cause of genetic Parkinson disease (PD). G2019S, the most frequent mutation, is responsible for both familial and sporadic cases of PD. The clinical picture is usually indistinguishable from that observed in idiopathic PD; however, a wide range of clinical presentations and pathological findings has been described. Restless leg syndrome (RLS) is a disabling sleep-related...
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