Article
Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins.
Journal of virology - 1 Oct 2005
Gerlach J T, Ulsenheimer A, Grüner N H, Jung M-C, Schraut W, Schirren C-A, Heeg M, Scholz S, Witter K, Zahn R, Vogler A, Zachoval R, Pape G R, Diepolder H M
Abstract excerpt
The hepatitis C virus (HCV)-specific CD4+ T-cell response against nonstructural proteins is strongly associated with successful viral clearance during acute hepatitis C. To further develop these observations into peptide-based vaccines and clinical immunomonitoring tools like HLA class II tetramers, a detailed characterization of immunodominant CD4+ T-cell epitopes is required. We studied peripheral blood...
Topics
- Adolescent
- Adult
- Alleles
- Amino Acid Sequence
- Antigen Presentation
- CD4-Positive T-Lymphocytes
- Female
- HLA Antigens
- Hepacivirus
- Hepatitis C