Article
Differential capacity of T cell priming in naive donors of promiscuous CD4+ T cell epitopes of HCV NS3 and Core proteins.
European journal of immunology - 1 Jun 2007
Castelli Florence A, Leleu Mélanie, Pouvelle-Moratille Sandra, Farci Sandrine, Zarour Hassane M, Andrieu Muriel, Auriault Claude, Ménez André, Georges Bertrand, Maillere Bernard
Abstract excerpt
To understand the inter-individual and virus-independent variability of CD4+ T cell responses to HCV components, we evaluated the effect on these responses of HLA II molecules in uninfected healthy donors. Using HLA II-specific binding assays, we identified, in the Core and NS3 proteins, 21 long...
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