Article
Recurrent LRRK2 (Park8) mutations in early-onset Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Sept 2006
Hedrich Katja, Winkler Susen, Hagenah Johann, Kabakci Kemal, Kasten Meike, Schwinger Eberhard, Volkmann Jens, Pramstaller Peter P, Kostic Vladimir, Vieregge Peter, Klein Christine
Abstract excerpt
Mutations in LRRK2 (leucine-rich repeat kinase 2) have been associated with autosomal dominant Parkinson's disease (PD) and cluster in several 3' exons of the gene. The majority of mutations have been detected in late-onset cases (age at onset >50 years). We screened 5 of the 51 exons of LRRK2 that previously have been reported to harbor mutations in 98 early-onset and 42 late-onset PD patients. We identified two...
Topics
- Adult
- Age Factors
- Alleles
- DNA Mutational Analysis
- Dominance, Cerebral
- Echoencephalography
- Exons
- Female
- Genetic Carrier Screening
- Genetic Markers