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Article

The coiled-coil domain is required for HS1 to bind to F-actin and activate Arp2/3 complex.

The Journal of biological chemistry - 11 Nov 2005

Hao Jian-Jiang, Zhu Jianwei, Zhou Kang, Smith Nicole, Zhan Xi

Abstract excerpt

HS1 (hematopoietic lineage cell-specific protein 1), a substrate of protein tyrosine kinases in lymphocytes, binds to F-actin, and promotes Arp2/3 complex-mediated actin polymerization. However, the mechanism for the interaction between HS1 and F-actin has not yet been fully characterized. HS1 contains 3.5 tandem repeats, a coiled-coil region, and an SH3 domain at the C terminus. Unlike cortactin, which is...

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Identifiers

PMID: 16157603
DOI: 10.1074/jbc.M504552200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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