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Article

Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia

17 Jan 2013

Abstract excerpt

HS1 (hematopoietic cell-specific Lyn substrate-1) is a cytoskeletal interactor in the B-cell receptor (BCR) signaling pathway whose phosphorylation correlates with prognosis in Chronic Lymphocytic Leukemia (CLL). The differentially phosphorylated sites and the kinases that regulate HS1 activity in CLL remain poorly understood. We demonstrate that HS1 activity is differentially regulated by LYN kinase that, in a...

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Identifiers

PMID: 23325840
DOI: 10.1182/blood-2012-09-457119

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Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemiaPMID 23325840Read ↗

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