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Article

NK cells promote islet allograft tolerance via a perforin-dependent mechanism.

Nature medicine - 1 Oct 2005

Beilke Joshua N, Kuhl Nathan R, Van Kaer Luc, Gill Ronald G

Abstract excerpt

Although major histocompatibility complex (MHC) class II-restricted CD4 T cells are well appreciated for their contribution to peripheral tolerance to tissue allografts, little is known regarding MHC class I-dependent reactivity in this process. Here we show a crucial role for host MHC class I-dependent NK cell reactivity for allograft tolerance in mice induced through either costimulation blockade using...

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Source

Identifiers

PMID: 16155578
DOI: 10.1038/nm1296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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