Article
Crystallographic refinement by knowledge-based exploration of complex energy landscapes.
Structure (London, England : 1993) - 1 Sept 2005
Depristo Mark A, de Bakker Paul I W, Johnson Russell J K, Blundell Tom L
Abstract excerpt
Although X-ray crystallography remains the most versatile method to determine the three-dimensional atomic structure of proteins and much progress has been made in model building and refinement techniques, it remains a challenge to elucidate accurately the structure of proteins in medium-resolution crystals. This is largely due to the difficulty of exploring an immense conformational space to identify the set of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.