Article
Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
Nucleic acids research - 1 Jan 2005
Golan Gali, Zharkov Dmitry O, Feinberg Hadar, Fernandes Andrea S, Zaika Elena I, Kycia Jadwiga H, Grollman Arthur P, Shoham Gil
Abstract excerpt
Escherichia coli endonuclease VIII (Nei) excises oxidized pyrimidines from DNA. It shares significant sequence homology and similar mechanism with Fpg, a bacterial 8-oxoguanine glycosylase. The structure of a covalent Nei-DNA complex has been recently determined, revealing critical amino acid residues which are important for DNA binding and catalysis. Several Fpg structures have also been reported; however,...
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