Article
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.
The EMBO journal - 15 Aug 1995
Thayer M M, Ahern H, Xing D, Cunningham R P, Tainer J A
Abstract excerpt
The 1.85 A crystal structure of endonuclease III, combined with mutational analysis, suggests the structural basis for the DNA binding and catalytic activity of the enzyme. Helix-hairpin-helix (HhH) and [4Fe-4S] cluster loop (FCL) motifs, which we have named for their secondary structure, bracket...
Topics
- Amino Acid Sequence
- Binding Sites
- Conserved Sequence
- Crystallography, X-Ray
- DNA Mutational Analysis
- DNA Repair
- DNA-Binding Proteins
- Deoxyribonuclease (Pyrimidine Dimer)
- Endodeoxyribonucleases
- Genes, Bacterial
- Helix-Loop-Helix Motifs
- Iron
- Lysine
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Folding