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Article

Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.

The EMBO journal - 15 Aug 1995

Thayer M M, Ahern H, Xing D, Cunningham R P, Tainer J A

Abstract excerpt

The 1.85 A crystal structure of endonuclease III, combined with mutational analysis, suggests the structural basis for the DNA binding and catalytic activity of the enzyme. Helix-hairpin-helix (HhH) and [4Fe-4S] cluster loop (FCL) motifs, which we have named for their secondary structure, bracket the cleft separating the two alpha-helical domains of the enzyme. These two novel DNA binding motifs and the...

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Identifiers

PMID: 7664751
DOI: 10.1002/j.1460-2075.1995.tb00083.x
PMCID: PMC394490

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