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Article

Escherichia coli endonuclease VIII: cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutants.

Journal of bacteriology - 1 Jun 1997

Jiang D, Hatahet Z, Blaisdell J O, Melamede R J, Wallace S S

Abstract excerpt

Escherichia coli possesses two DNA glycosylase/apurinic lyase activities with overlapping substrate specificities, endonuclease III and endonuclease VIII, that recognize and remove oxidized pyrimidines from DNA. Endonuclease III is encoded by the nth gene. Endonuclease VIII has now been purified to apparent homogeneity, and the gene, nei, has been cloned by using reverse genetics. The gene nei is located at 16...

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Identifiers

PMID: 9171429
DOI: 10.1128/jb.179.11.3773-3782.1997
PMCID: PMC179177

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