Article
A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis.
Molecular and cellular biology - 1 Jan 1998
Tsubouchi H, Ogawa H
Abstract excerpt
Using complementation tests and nucleotide sequencing, we showed that the rad58-4 mutation was an allele of the MRE11 gene and have renamed the mutation mre11-58. Two amino acid changes from the wild-type sequence were identified; one is located at a conserved site of a phosphodiesterase motif, a...
Topics
- DNA Damage
- DNA Repair
- DNA Replication
- DNA, Fungal
- Endodeoxyribonucleases
- Exodeoxyribonucleases
- Fungal Proteins
- Meiosis
- Mitosis
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins