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Article

Nuclease activity of Saccharomyces cerevisiae Mre11 functions in targeted nucleotide alteration.

Applied and environmental microbiology - 1 Oct 2003

Liu Li, Usher Michael, Hu Yiling, Kmiec Eric B

Abstract excerpt

Oligonucleotides can be used to direct site-specific changes in genomic DNA through a process in which mismatched base pairs in the oligonucleotide and the target DNA are created. The mechanism by which these complexes are developed and resolved is being studied by using Saccharomyces cerevisiae as a model system. Genetic analyses have revealed that in all likelihood the reaction occurs in two phases: DNA pairing...

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Source

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Identifiers

PMID: 14532083
DOI: 10.1128/AEM.69.10.6216-6224.2003
PMCID: PMC201246

Genes

MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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