Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.

doi:10.1093/genetics/139.4.1521

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Article

Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.

Genetics - 1 Apr 1995

Johzuka K, Ogawa H

Abstract excerpt

A temperature-sensitive mre11-1 mutation of Saccharomyces cerevisiae causes defects in meiotic recombination and DNA repair during vegetative growth at a restrictive temperature. We cloned the MRE11 gene and found that it encodes a 643-amino acid protein with a highly acidic region containing a heptad repeat of Asp at its C-terminus and is located downstream of YMR44 near the RNA1 locus on the right arm of...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA Repair
DNA, Recombinant
DNA-Binding Proteins
Endodeoxyribonucleases
Exodeoxyribonucleases
Fungal Proteins
Meiosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

RNA, Messenger

Recombination, Genetic

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7789757
DOI: 10.1093/genetics/139.4.1521
PMCID: PMC1206481

Genes

MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.PMID 7789757Read ↗

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