Article
Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.
Molecular and cellular biology - 1 Jul 1994
Francisco L, Wang W, Chan C S
Abstract excerpt
The IPL1 gene is required for high-fidelity chromosome segregation in the budding yeast Saccharomyces cerevisiae. Conditional ipl1ts mutants missegregate chromosomes severely at 37 degrees C. Here, we report that IPL1 encodes an essential putative protein kinase whose function is required during the later part of each cell cycle. At 26 degrees C, the permissive growth temperature, ipl1 mutant cells are defective...
Topics
- Amino Acid Sequence
- Aurora Kinases
- Base Sequence
- Cell Cycle
- Chromosomes, Fungal
- Genes, Fungal
- Hydroxyurea
- Intracellular Signaling Peptides and Proteins
- Mating Factor
- Molecular Sequence Data
- Mutagenesis