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Article

Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth.

EMBO reports - 1 Feb 2012

Rossi Fabrizio, Gonzalez Cayetano

Abstract excerpt

Loss of function of pins (partner of inscuteable) partially disrupts neuroblast (NB) polarity and asymmetric division, results in fewer and smaller NBs and inhibits Drosophila larval brain growth. Food deprivation also inhibits growth. However, we find that the combination of loss of function of pins and dietary restriction results in loss of NB asymmetry, overproliferation of Miranda-expressing...

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Source

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Identifiers

PMID: 22173033
DOI: 10.1038/embor.2011.230
PMCID: PMC3271332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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