Article
Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.
Journal of virology - 1 Sept 2005
Pillay Thillagavathie, Zhang Hua-Tang, Drijfhout Jan W, Robinson Nicola, Brown Helen, Khan Munira, Moodley Jagadesa, Adhikari Miriam, Pfafferott Katja, Feeney Margaret E, St John Anne, Holmes Edward C, Coovadia Hoosen M, Klenerman Paul, Goulder Philip J R, Phillips Rodney E
Abstract excerpt
The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant HIV-1-specific CTL can select for viral escape variants very early in life. These variants, furthermore, may be selected specifically in the infant, despite the same CTL specificity being present in the mother....
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