Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.

doi:10.1126/science.1546316

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Article

Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.

Science (New York, N.Y.) - 28 Feb 1992

Wolinsky S M, Wike C M, Korber B T, Hutto C, Parks W P, Rosenblum L L, Kunstman K J, Furtado M R, Muñoz J L

Abstract excerpt

Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Base Sequence
Female
Genotype
Glycosylation
HIV Antigens
HIV Envelope Protein gp120
HIV-1
Humans
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Maternal-Fetal Exchange

Molecular Sequence Data

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Pregnancy

Selection, Genetic

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 1546316
DOI: 10.1126/science.1546316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1546316-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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