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Article

Neutralizing antibody escape during HIV-1 mother-to-child transmission involves conformational masking of distal epitopes in envelope.

Journal of virology - 1 Sept 2012

Goo Leslie, Milligan Caitlin, Simonich Cassandra A, Nduati Ruth, Overbaugh Julie

Abstract excerpt

HIV-1 variants transmitted to infants are often resistant to maternal neutralizing antibodies (NAbs), suggesting that they have escaped maternal NAb pressure. To define the molecular basis of NAb escape that contributes to selection of transmitted variants, we analyzed 5 viruses from 2 mother-to-child transmission pairs, in which the infant virus, but not the maternal virus, was resistant to neutralization by...

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Share to Antibodies, Neutralizing
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitope Mapping

Share to Genes, env

Share to HIV Antibodies

Share to HIV Antigens

Share to Infectious Disease Transmission, Vertical

Share to Pregnancy Complications, Infectious

Source

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Identifiers

PMID: 22740394
DOI: 10.1128/JVI.00953-12
PMCID: PMC3446598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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