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Article

Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of tamoxifen (TAM).

Journal of molecular and cellular cardiology - 1 Nov 2005

Daosukho Chotiros, Ittarat Wanida, Lin Shu-Mei, Sawyer Douglas B, Kiningham Kelley, Lien Yu-Chin, St Clair Daret K

Abstract excerpt

Tamoxifen (TAM), a synthetic nonsteroidal antiestrogen effectively and widely used for breast cancer treatment, is known to have antioxidant and cardioprotective effects, but whether the beneficial cardiovascular effect of TAM is linked to its antioxidant effect is unknown. In this study, we investigated the effect of TAM on the levels of manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme,...

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PMID: 16140321
DOI: 10.1016/j.yjmcc.2005.07.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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