Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomerase therapy attenuates cardiotoxic effects of doxorubicin

31 Dec 2020

Abstract excerpt

Doxorubicin is one of the most potent chemotherapeutic agents. However, its clinical use is restricted due to the severe risk of cardiotoxicity, partially attributed to elevated production of reactive oxygen species (ROS). Telomerase canonically maintains telomeres during cell division but is silenced in adult hearts. In non-dividing cells such as cardiomyocytes, telomerase confers pro-survival traits, likely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related cognitive impairment studies
Share to Chemotherapy-induced cardiotoxicity and mitigation
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33388418
DOI: 10.1016/j.ymthe.2020.12.035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomerase therapy attenuates cardiotoxic effects of doxorubicinPMID 33388418Read ↗

Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative StressSemantic proximity Read ↗

Doxorubicin cardiotoxicity and target cells: a broader perspectiveSemantic proximity Read ↗

Mitochondria and Doxorubicin-Induced Cardiomyopathy: A Complex InterplaySemantic proximity Read ↗

Epigenetic Changes Associated With Anthracycline‐Induced CardiotoxicitySemantic proximity Read ↗

The role of autophagy in doxorubicin-induced cardiotoxicitySemantic proximity Read ↗

Review on the Role of Epigenetic Modifications in Doxorubicin-Induced CardiotoxicitySemantic proximity Read ↗

Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stressSemantic proximity Read ↗

Anthracycline-mediated cardiomyopathy: Basic molecular knowledge for the cardiologistSemantic proximity Read ↗

Pathophysiology of anthracycline cardiotoxicity.Semantic proximity Read ↗

Noncoding RNAs in doxorubicin-induced cardiotoxicity and their potential as biomarkers and therapeutic targetsSemantic proximity Read ↗

Telomerase as a Therapeutic Target in Cardiovascular Disease.Semantic proximity Read ↗

Obestatin attenuated doxorubicin-induced cardiomyopathy via enhancing long noncoding Mhrt RNA expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.