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Article

Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies.

Oxidative medicine and cellular longevity - 1 Jan 2021

Carrasco Rodrigo, Castillo Rodrigo L, Gormaz Juan G, Carrillo Montserrat, Thavendiranathan Paaladinesh

Abstract excerpt

Anthracycline-induced cardiotoxicity (AIC) persists as a significant cause of morbidity and mortality in cancer survivors. Although many protective strategies have been evaluated, cardiotoxicity remains an ongoing threat. The mechanisms of AIC remain unclear; however, several pathways have been proposed, suggesting a multifactorial origin. When the central role of topoisomerase 2β in the pathophysiology of AIC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33574985
DOI: 10.1155/2021/8863789
PMCID: PMC7857913

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