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Article

Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice.

Cardiovascular research - 1 Jun 2009

Loch Tomasz, Vakhrusheva Olesya, Piotrowska Izabela, Ziolkowski Wieslaw, Ebelt Henning, Braun Thomas, Bober Eva

Abstract excerpt

AIMS: The mitochondrially expressed manganese-dependent superoxide dismutase (MnSOD, SOD2) is an essential antioxidative enzyme that is necessary for normal heart function. In this study, we investigated the heart function of mice that were exposed to increased oxidative stress for time periods of up to 6 months due to decreased MnSOD activity caused by heterozygous deletion of the MnSOD gene. METHODS AND...

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Identifiers

PMID: 19293248
DOI: 10.1093/cvr/cvp092

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SOD2

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