Article
A comparison of case-control and family-based association methods: the example of sickle-cell and malaria.
Annals of human genetics - 1 Sept 2005
Ackerman H, Usen S, Jallow M, Sisay-Joof F, Pinder M, Kwiatkowski D P
Abstract excerpt
There has been much debate about the relative merits of population- and family-based strategies for testing genetic association, yet there is little empirical data that directly compare the two approaches. Here we compare case-control and transmission/disequilibrium test (TDT) study designs using a well-established genetic association, the protective effect of the sickle-cell trait against severe malaria. We find...
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