Article
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.
American journal of human genetics - 1 Aug 2007
Ayodo George, Price Alkes L, Keinan Alon, Ajwang Arthur, Otieno Michael F, Orago Alloys S S, Patterson Nick, Reich David
Abstract excerpt
Statistical power to detect disease variants can be increased by weighting candidates by their evidence of natural selection. To demonstrate that this theoretical idea works in practice, we performed an association study of 10 putative resistance variants in 471 severe malaria cases and 474 controls from the Luo in Kenya. We replicated associations at HBB (P=.0008) and CD36 (P=.03) but also showed that the same...
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