Article
Observational, hypothesis-driven and genomics research strategies for analyzing inherited differences in responses to infectious diseases.
Public health genomics - 1 Jan 2009
Allison A C
Abstract excerpt
The first phase of research on genetic factors influencing susceptibility to infectious diseases was observational and descriptive. It began with the identification of children and adults with selective and non-selective immunodeficiencies. The types of infections to which these patients are susceptible provided evidence for the roles of T-cells, B-cells, leukocytes, and complement in controlling infectious...
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