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Article

Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.

PloS one - 1 Jan 2011

Cowin Randi-Michelle, Bui Nghiem, Graham Deanna, Green Jennie R, Grueninger Stephan, Yuva-Paylor Lisa A, Syed Arsalan U, Weiss Andreas, Paylor Richard

Abstract excerpt

In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which uniquely exhibits minimal intergenerational instability. We also report the first identification of the R6/2 transgene insertion site. The relatively stable line of 110 CAG R6/2 mice was characterized for the onset of behavioral impairments in motor, cognitive and...

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Identifiers

PMID: 22163300
DOI: 10.1371/journal.pone.0028409
PMCID: PMC3233565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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