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Histone Acetylation and Flagellin Are Essential for Legionella pneumophila -Induced Cytokine Expression

1 Jul 2008

Abstract excerpt

Legionella pneumophila causes severe pneumonia. Acetylation of histones is thought to be an important regulator of gene transcription, but its impact on L. pneumophila-induced expression of proinflammatory cytokines is unknown. L. pneumophila strain 130b induced the expression of the important chemoattractant IL-8 and genome-wide histone modifications in human lung epithelial A549 cells. We analyzed the...

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PMID: 18606645
DOI: 10.4049/jimmunol.181.2.940

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