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Article

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

The EMBO journal - 2 Dec 2002

Chen Lin-feng, Mu Yajun, Greene Warner C

Abstract excerpt

The nuclear function of the heterodimeric NF-kappaB transcription factor is regulated in part through reversible acetylation of its RelA subunit. We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and 310 for modification. Analysis of the functional properties of hypoacetylated RelA mutants containing...

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Share to Acetylation
Share to Acetyltransferases
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Histone Acetyltransferases

Share to NF-kappa B

Share to p300-CBP Transcription Factors

Share to Transcription Factor RelA

Source

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Identifiers

PMID: 12456660
DOI: 10.1093/emboj/cdf660
PMCID: PMC136963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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