Article
The role of resistance in HCV treatment.
Best practice & research. Clinical gastroenterology - 1 Aug 2012
Vermehren Johannes, Sarrazin Christoph
Abstract excerpt
The recent development of small molecule compounds that directly inhibit the viral life cycle represents a major milestone for the treatment of chronic hepatitis C virus (HCV) infection. These new drugs that are collectively termed direct-acting antivirals (DAA) include a range of inhibitors of the non-structural (NS) 3/4A protease, NS5B polymerase and NS5A protein. Two NS3/4A protease inhibitors (boceprevir and...
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