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Article

Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.

Annals of neurology - 1 Sept 2005

Meschia James F, Brott Thomas G, Brown Robert D, Crook Richard, Worrall Bradford B, Kissela Brett, Brown W Mark, Rich Stephen S, Case L Douglas, Evans E Whitney, Hague Stephen, Singleton Andrew, Hardy John

Abstract excerpt

Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP)....

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Source

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Identifiers

PMID: 16130105
DOI: 10.1002/ana.20585
PMCID: PMC1774984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.PMID 16130105Read ↗

ALOX5AP gene and the PDE4D gene in a central European population of stroke patients.Semantic proximity Read ↗

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PDE4D and ALOX5AP genetic variants and risk for Ischemic Cerebrovascular Disease in Sweden.Semantic proximity Read ↗

Association of Phosphodiesterase 4D with ischemic stroke: a population-based case-control study.Semantic proximity Read ↗

Stroke Genetics – Focus on PDE4D GeneSemantic proximity Read ↗

Evaluation of single nucleotide polymorphisms in the phosphodiesterase 4D gene (PDE4D) and their association with ischaemic stroke in a large German cohort.Semantic proximity Read ↗

Polymorphisms of the phosphodiesterase 4D, cAMP-specific (PDE4D) gene and risk of ischemic stroke: a prospective, nested case-control evaluation.Semantic proximity Read ↗

Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians.Semantic proximity Read ↗

Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region.Semantic proximity Read ↗

Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population.Semantic proximity Read ↗

Association of the phosphodiesterase 4D (PDE4D) gene and cardioembolic stroke in an Australian cohort.Semantic proximity Read ↗

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