Article
APOA1 polymorphism influences risk for early-onset nonfamiliar AD.
Annals of neurology - 1 Sept 2005
Vollbach Heike, Heun Reinhard, Morris Chris M, Edwardson Jim A, McKeith Ian G, Jessen Frank, Schulz Anne, Maier Wolfgang, Kölsch Heike
Abstract excerpt
Alterations in cholesterol homeostasis influence the risk for Alzheimer's disease (AD). Apolipoprotein A1 is the major apolipoprotein of the high-density lipoprotein and is involved in reverse cholesterol transport. Variation in the apolipoprotein A1 gene (APOA1) might influence the function of the protein, and thus brain cholesterol metabolism, leading to an increased risk for AD. Two polymorphisms of APOA1, a...
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