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Article

The polymorphism of the ATP-binding cassette transporter 1 gene modulates Alzheimer disease risk in Chinese Han ethnic population.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Jul 2012

Sun Yi-Min, Li Hong-Lei, Guo Qi-Hao, Wu Ping, Hong Zhen, Lu Chuan-Zhen, Wu Zhi-Ying

Abstract excerpt

BACKGROUND: Recent studies highlight a potential role of cholesterol metabolic disturbance in the pathophysiology of Alzheimer disease (AD). The adenosine triphosphate (ATP)-binding cassette transporter 1 (ABCA1) gene resides within proximity of linkage peaks on chromosome 9q influence AD and plays a key role in cellular cholesterol efflux in the brain. METHODS: We studied the role of R219K and V825I...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22377775
DOI: 10.1097/JGP.0b013e3182423b6a

Genes

APOE
ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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