Article
ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease.
Neurobiology of disease - 1 Feb 2005
Macé Sandrine, Cousin Emmanuelle, Ricard Sylvain, Génin Emmanuelle, Spanakis Emmanuel, Lafargue-Soubigou Carole, Génin Bérengère, Fournel Raphaël, Roche Sandrine, Haussy Gilles, Massey Florence, Soubigou Stéphane, Bréfort Georges, Benoit Patrick, Brice Alexis, Campion Dominique, Hollis Melvyn, Pradier Laurent, Benavides Jésus, Deleuze Jean-François
Abstract excerpt
Recent epidemiological, biological and genetic data indicate a relationship between cholesterol and Alzheimer's disease (AD) including the association of polymorphisms of ABCA1 (a gene that is known to participate in cholesterol and phospholipid transport) with AD prevalence. Based on these data, we postulated that genetic variation in the related and brain-specific ABCA2 gene leads to increase risk of AD. A...
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