Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An apolipoprotein A-I gene promoter polymorphism associated with cognitive decline, but not with Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Helbecque Nicole, Codron Valérie, Cottel Dominique, Amouyel Philippe

Abstract excerpt

BACKGROUND/AIMS: Accumulating biological and epidemiological evidence suggests a close link between cholesterol metabolism and the pathophysiology of Alzheimer's disease (AD). The observation that the use of statins reduces the risk of AD sustains this hypothesis. Apolipoprotein A-I (APOA1) is the major component of the high-density lipoproteins, particles involved in reverse cholesterol transport. Therefore,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein A-I

Share to Chromosomes, Human, Pair 11

Share to Cognition Disorders

Share to Promoter Regions, Genetic

Share to Severity of Illness Index

Share to White People

Source

Identifiers

PMID: 18073484
DOI: 10.1159/000112176

Genes

APOA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An apolipoprotein A-I gene promoter polymorphism associated with cognitive decline, but not with Alzheimer's disease.PMID 18073484Read ↗

APOA1 polymorphism influences risk for early-onset nonfamiliar AD.Semantic proximity Read ↗

The APOE-491 A/T promoter polymorphism effect on cognitive profile of Alzheimer's patients.Semantic proximity Read ↗

Polymorphism in apoA1 Influences High-Density Lipoprotein Cholesterol Levels but Is Not a Major Risk Factor of Alzheimer’s DiseaseSemantic proximity Read ↗

An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis.Semantic proximity Read ↗

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.Semantic proximity Read ↗

Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese.Semantic proximity Read ↗

Association of complement receptor 1 gene polymorphisms with cognitive function.Semantic proximity Read ↗

Association analysis of the paraoxonase-1 gene with Alzheimer's disease.Semantic proximity Read ↗

APOE and risk of cognitive impairment in multiple sclerosis.Semantic proximity Read ↗

Mild association between the A/G polymorphism in the promoter of the apolipoprotein A-I gene and apolipoprotein A-I levels: a meta-analysis.Semantic proximity Read ↗

The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimer's risk and cognitive deterioration.Semantic proximity Read ↗

Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.