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Article

Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.

Annals of neurology - 1 Aug 2003

Pastor Pau, Roe Catherine M, Villegas Andrés, Bedoya Gabriel, Chakraverty Sumi, García Gloria, Tirado Victoria, Norton Joanne, Ríos Silvia, Martínez Maribel, Kosik Kenneth S, Lopera Francisco, Goate Alison M

Abstract excerpt

We previously have identified a large kindred from Colombia in which Alzheimer's disease (AD) is caused by the E280A presenilin 1 (PS1) mutation. The objective of this study was to examine whether environmental and genetic factors are responsible for variation in the phenotypic expression of the E280A PS1 mutation. We genotyped coding and promoter polymorphisms of the APOE gene in carriers of the E280A PS1...

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PMID: 12891668
DOI: 10.1002/ana.10636

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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