Article
Pig-tailed macaques (Macaca nemestrina) possess six MHC-E families that are conserved among macaque species: implication for their binding to natural killer receptor variants.
Immunogenetics - 1 Jun 2004
Lafont Bernard A P, Buckler-White Alicia, Plishka Ron, Buckler Charles, Martin Malcolm A
Abstract excerpt
MHC loci encode highly polymorphic molecules involved in the presentation of self and non-self peptides to cells of the adaptive and innate immune systems. Although variable, MHC-E genes are well conserved among primates and provide signals to natural killer cells. In this study, we sequenced and analyzed MHC-E alleles of pig-tailed macaque (Macaca nemestrina), a nonhuman primate used for HIV pathogenesis and...
Topics
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Chromosome Mapping
- Cloning, Molecular
- Conserved Sequence
- Genes, MHC Class I
- Histocompatibility Antigens Class I
- Killer Cells, Natural