Article
Natural host genetic resistance to lentiviral CNS disease: a neuroprotective MHC class I allele in SIV-infected macaques.
PloS one - 1 Jan 2008
Mankowski Joseph L, Queen Suzanne E, Fernandez Caroline S, Tarwater Patrick M, Karper Jami M, Adams Robert J, Kent Stephen J
Abstract excerpt
Human immunodeficiency virus (HIV) infection frequently causes neurologic disease even with anti-retroviral treatment. Although associations between MHC class I alleles and acquired immunodeficiency syndrome (AIDS) have been reported, the role MHC class I alleles play in restricting development of HIV-induced organ-specific diseases, including neurologic disease, has not been characterized. This study examined...
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