Article
Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes.
Journal of virology - 1 Jan 2005
Smith Miranda Z, Dale C Jane, De Rose Robert, Stratov Ivan, Fernandez Caroline S, Brooks Andrew G, Weinfurter Jason, Krebs Kendall, Riek Cara, Watkins David I, O'connor David H, Kent Stephen J
Abstract excerpt
Successful human immunodeficiency virus (HIV) vaccines will need to induce effective T-cell immunity. We studied immunodominant simian immunodeficiency virus (SIV) Gag-specific T-cell responses and their restricting major histocompatibility complex (MHC) class I alleles in pigtail macaques (Macaca nemestrina), an increasingly common primate model for the study of HIV infection of humans. CD8+ T-cell responses to...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen Presentation
- CD8-Positive T-Lymphocytes
- Epitopes, T-Lymphocyte
- Gene Products, gag
- Genes, MHC Class I
- Immunodominant Epitopes
- Interferon-gamma
- Macaca nemestrina
- Molecular Sequence Data