Article
The locus encoding an oligomorphic family of MHC-A alleles (Mane-A*06/Mamu-A*05) is present at high frequency in several macaque species.
Immunogenetics - 1 Mar 2007
Lafont Bernard A P, McGraw Christopher M, Stukes Sabriya A, Buckler-White Alicia, Plishka Ronald J, Byrum Russell A, Hirsch Vanessa M, Martin Malcolm A
Abstract excerpt
Several macaques species are used for HIV pathogenesis and vaccine studies, and the characterization of their major histocompatibility complex (MHC) class I genes is required to rigorously evaluate the cellular immune responses induced after immunization and/or infection. In this study, we demonstrate that the gene expressing the Mane-A*06 allele of pig-tailed macaques is an orthologue of the locus encoding the...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Evolution, Molecular
- Gene Duplication
- Gene Frequency
- Genes, MHC Class I
- Introns
- Macaca
- Molecular Sequence Data
- Phylogeny
- Polymorphism, Genetic